Metabolic Acidosis Results in Sexually Dimorphic Response in the Heart Tissue

Metabolic Acidosis Results in Sexually Dimorphic Response in the Heart Tissue

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Metabolic acidosis (MA) is a highly prevalent disorder in a significant proportion of the population, resulting from imbalance in blood pH homeostasis.The heart, being an organ with very low Bosch PIM851F17E 80cm 5 Zone Induction Hob regenerative capacity and high metabolic activity, is vulnerable to chronic, although low-grade, MA.To systematically characterize the effect of low-grade MA on the heart, we treated male and female mice with NH4Cl supplementation for 2 weeks and analyzed their blood chemistry and transcriptomic signature of the heart tissue.The reduction of pH and plasma bicarbonate levels without an associated change in anion gap indicated a physiological manifestation of low-grade MA with minimal respiratory compensation.On transcriptomic analysis, we observed changes in cardiac-specific genes with significant gender-based differences due to MA.

We found many genes contributing to dilated cardiomyopathy to be altered in males, more than in females, while cardiac contractility and Na/K/ATPase-Src signaling were affected in the opposite way.Our model presents a systems-level understanding of how the cardiovascular tissue is affected by MA.As low-grade MA is a common ailment with many dietary Mat and pharmaceutical interventions, our work presents avenues to limit chronic cardiac damage and disease manifestation, as well as highlighting the sex differences in MA-induced cardiovascular damage.